Therapeutic Index (TIX) for intranasal corticosteroids in the treatment of allergic rhinitis
نویسندگان
چکیده
منابع مشابه
Intranasal corticosteroids for allergic rhinitis
• Allergic rhinitis is defined as intermittent (or seasonal) or persistent (or perennial), according to symptom duration and frequency. • Intranasal corticosteroids are the most effective treatment option for moderate-severe symptoms and reduce sneezing, rhinorrhea, itching, post-nasal drip and nasal blockage, and total nasal symptom scores better than antihistamines. • There are currently six ...
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Ciclesonide is a novel corticosteroid which is optimized for topical use. It is a pro-drug which is activated locally in the airway mucosa, lipid-conjugated for local retention, and has very high protein binding in circulation leading to low systemic bioavailability. These characteristics should lead to highly selective activity with reduced local and systemic side effects. It has been establis...
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OBJECTIVE Intranasal steroids (INS) are firmly established as the therapy for choice for allergic rhinitis, but their role in vasomotor rhinitis (VMR) is not fully characterized. This review examines the potential mechanisms of action and reported efficacy of INS in patients with VMR. RESULTS INS, through intracellular activation of the glucocorticoid receptor, down-regulate the recruitment a...
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Allergic rhinitis affects more than 20% and is responsible for very high direct and indirect costs. Nasal corticosteroids are the principle pharmaceutical option for the treatment of allergic rhinitis. They are more effective than all other therapeutic options and in addition to improving symptoms of allergic rhinitis they also improve quality of life in patients suffering from allergic rhiniti...
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Allergic rhinitis (AR) is a chronic nasal disease that affects the upper respiratory tract. This disorder is characterized by inflammation of the mucous membranes and it manifests with several nasal symptoms accompanied sometimes by non-nasal symptoms. Best therapy aims to prevent and improve the AR-clinical picture. Steroids have an important role in the treatment of AR. The development of ste...
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ژورنال
عنوان ژورنال: Rhinology journal
سال: 2011
ISSN: 0300-0729
DOI: 10.4193/rhino10.170